From powders to granules to tablets –

technologies and tools to accomplish an optimal tablet quality

Why participating?

This workshop on granulation and tableting is a perfect combination of theory, case studies and practical demonstrations.

The workshop provides the basics of granulation and compaction and outlines their applications in powder processing.

This workshop is the perfect investment for those who wish to acquire knowledge of the various methods of granulation and the compaction of granules to tablets.

 

Who should participate?

Typically, operators and researchers from the pharmaceutical and related industries will profit from this workshop – giving a detailed overview of granulation methods and selection of most feasible granulation method considering API characteristics.

Program

Tuesday, 7 November 2023

12:00 Reception and registration, snack buffet

12:30 Introduction. Philippe Tschopp

12:45 Principles of granulation. MARKUS THOMMES, TU DORTMUND
Explaining the principles of granulation processes, the physico-chemical fundaments and basic manufacturing operations ranging from low to high shear processing and from wet to dry granulation.

14:00 Fluid bed granulation – basic principles and concepts of the batch process. NORBERT PÖLLINGER, Glatt
The set up of the process and the important process parameters are discussed. Strategies to achieve a robust and reproducible granule and tablet quality are presented.

14:45 Coffee break

15:15 Applying different fluidized bed spraying configurations and their impact on granule and tablet quality. STEFANIE THIEL, Glatt
Comparing top spray, bottom spray and tangential spray processes and discussing the resulting tablet characteristics – providing the means to select most appropriate technology for any purpose.

16:00 Continuous fluid bed granulation processes. MICHAEL JACOB, Glatt 
Comparing batch and continuous operations and describing the various process options. Giving an overview on state-of-the-art technology for continuous fluidized bed processing.

16:45 Wet granulation batch process using a high shear granulation line and innovative TwinPro® technology.

Modern state-of-the-art high shear granulation line and innovative TwinPro® technology combining high shear granulator and fluid bed dryer in one unit are discussed. Advanced systems to detect granulation endpoint and allow for automization of processes are presented.

Wednesday, 8 November 2023

09:00 Principles of tableting. MARKUS THOMMES, TU DORTMUND
    Explaining the principle of tableting ref to the role of excipients and quality of granules.
 
10:00   Continuous wet granulation with twin screw extrusion technology – the MODCOS technology.
Introduction of wet granulation by twin screw extrusion followed by continuous fluid bed drying     technology, preparation of tablet blend and compression step. Discussing the options of continuous direct compression and continuous granulation process.
 
10:45   Coffee break
 
11:15   Manufacturing Amorphous Solid Dispersions (ASD) with fluid bed granulation processes. KARL- GERHARD WAGNER, UNIVERSITÄT BONN
Insolubility of drugs in water is a challenge for every formulator. Amorphous Solid Dispersion Is   one option to improve solubility and bioavailability. A straightforward manufacturing is provided with fluid bed granulation avoiding downstream processing such as roller compaction.
 
12:00   Lunch in meet and eat
 
13:30   Introduction into the practical session of the workshop – presenting the formulations, processes, PATs and IPCs for granulation and tableting
Hands-on demonstration in granulation and tableting processes – a chance to work with the experts and get your questions answered.
  • Fluidized bed granulation in batch mode using top spray / bottom spray / tangential spray configuration
  • High shear granulation using GranuLine and TwinPro®
  • Twin screw extrusion granulation using MODCOS line
  • PAT applications (particle size distribution with Eyecon, Parsum; moisture with microwave)
  • Tableting of different granules and comparing the tablet properties (hardness, friability, disintegration)
17:30   Transfer to hotel
 
19:00   Workshop dinner

Thursday, 9 November 2023

09:00   Hot melt granulation processes – effective, fast, no solvents.
Processing of lipid, hydrophilic and amphiphilic compounds without using solvents makes hot melt processing a very interesting and economic process. From moisture protection to solubilization of insoluble compounds to taste masking.

09:45   Spray systems for fluidized bed applications.
Looking closer at the most relevant spray technologies for pharmaceutical applications. Discussing the impact of an adequate spray system function in granulation processes on product and process quality.

10:30   Coffee break

11:00   Process optimization considering QbD and using DoE- the basis for successful scale up.
Process optimization based on QbD and applying DoE as the pre-requisite for successful scale up,    process validation and  successful commerzialisation.

11:45   Scale up of fluid bed and high shear granulation.
Introduction to scientifically based approaches, allowing for successful scale up from lab scale to production volumes.

12:30   Close up and snack buffet

13:00   Transfer to railway stations and airport